1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

Base Information

Chemical Name:1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea
CAS No.:1188908-02-2
Molecular Formula:C₂₃H₂₃N₅O₅
Molecular Weight:449.466
Hs Code.:

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

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Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

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Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

There total 6 articles about 1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 81479-48-3
phenyl (5-(tert-butyl)isoxazol-3-yl)carbamate

: 1188908-04-4
4-(3-aminophenoxy)-6-methoxyquinazolin-7-ol

: 1188908-02-2
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 5h;

Reference yield:

: 27883-60-9
4-hydroxy-5-methoxy-2-nitrobenzoic acid methyl ester

: 1188908-02-2
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 90 - 95 °C

2: methanol; sodium dithionite; water / 55 °C

3: acetic acid / 130 °C

4: trichlorophosphate / 110 - 115 °C

5: caesium carbonate / tetrahydrofuran / 25 h / 75 °C

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 50 - 55 °C

7: N,N-dimethyl-formamide / 60 °C

With methanol; sodium dithionite; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; acetic acid; potassium iodide; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.019

Reference yield:

: 61032-42-6
methyl 2-amino-4-(benzyloxy)-5-methoxybenzoate

: 1188908-02-2
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-hydroxy-6-methoxyquinazolin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 130 °C

2: trichlorophosphate / 110 - 115 °C

3: caesium carbonate / tetrahydrofuran / 25 h / 75 °C

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 50 - 55 °C

5: N,N-dimethyl-formamide / 60 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.019