27883-60-9

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER is used as an intermediate in the production of pharmaceuticals for its potential therapeutic applications, such as its anti-inflammatory and analgesic properties.
Used in Dye Industry:
4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER is used as a chemical intermediate in the synthesis of dyes, contributing to the coloration and properties of various dye products.
Used in Organic Synthesis:
4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER serves as a key component in organic synthesis, enabling the creation of a range of chemical compounds for diverse applications across different industries.

Upstream product

• 61032-41-5 methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate 
• 10097-32-2 bromine 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 121-33-5 vanillin 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 67-56-1 methanol 
• 140647-01-4 4-hydroxy-5-methoxy-2-nitrobenzoic acid 
• 60547-92-4 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid 
• 91203-74-6 4-benzyloxy-3-methoxybenzoic acid benzyl ester 
• 56441-97-5 methyl 4-(benzyloxy)-3-methoxybenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 

Downstream Products

• 757189-84-7 methyl 4-(N-t-butoxycarbonyl)aminoethoxy-5-methoxy-2-nitrobenzoate 
• 757189-85-8 methyl 4-(N-t-butoxycarbonyl)aminopropoxy-5-methoxy-2-nitrobenzoate 
• 1352738-37-4 2-nitro-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester 
• 1352738-41-0 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester 
• 364793-68-0 5-methoxy-2-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester 
• 1320288-30-9 2,4-dichloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 
• 1320288-29-6 6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)-1H-quinazoline-2,4-dione 
• 760155-54-2 2-amino-5-methoxy-4-(3-pyrrolidin-1-ylpropoxy)benzamide 
• 199327-73-6 5-methoxy-2-nitro4-(3-(pyrrolidin-1-yl)propoxy)benzamide 
• 745776-25-4 5-methoxy-2-nitro-4-(3-pyrrolidin-1-ylpropoxy)benzoic acid 
• 1320288-23-0 methyl 5-methoxy-2-nitro-4-[3-(pyrrolidin-1-yl)propoxy]benzoate 
• 343308-49-6 methyl 4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoate 
• 343308-51-0 methyl 4-((5-bromopentyl)oxy)-5-methoxy-2-nitrobenzoate 

Relevant academic research and scientific papers

VISUAL DETECTION OF PBD INDUCED DNA CROSSLINKS

The present invention relates to the field of oncology, laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking; to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

SnCl2 catalyzed direct synthesis of pyrroles under aqueous conditions

Synthetic substituted pyrroles are related with interesting biological activities, yet they remain inadequately explored within drug discovery. Late years have seen a growing interest in synthetic approaches that can provide access to structurally novel pyrroles so that the biological usefulness of this compound class can be more fully investigated. Herein, an efficient and versatile practical protocol for the pyrroles using stannous(II) chloride dihydrate as catalyst is described under aqueous conditions at 55 oC in high yields. Also, this method is applicable for the preparation of diversity and oriented pyrrole derivatives.

NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy

Using knowledge- and structure-based approaches, we designed and synthesized reversible chemical probes that simultaneously inhibit the activity of two epigenetic targets, histone 3 lysine 9 methyltransferase (G9a) and DNA methyltransferases (DNMT), at nanomolar ranges. Enzymatic competition assays confirmed our design strategy: substrate competitive inhibitors. Next, an initial exploration around our hit 11 was pursued to identify an adequate tool compound for in vivo testing. In vitro treatment of different hematological neoplasia cell lines led to the identification of molecules with clear antiproliferative efficacies (GI50 values in the nanomolar range). On the basis of epigenetic functional cellular responses (levels of lysine 9 methylation and 5-methylcytosine), an acceptable therapeutic window (around 1 log unit) and a suitable pharmacokinetic profile, 12 was selected for in vivo proof-of-concept (Nat. Commun. 2017, 8, 15424). Herein, 12 achieved a significant in vivo efficacy: 70% overall tumor growth inhibition of a human acute myeloid leukemia (AML) xenograft in a mouse model.

4-substituted anilinoquinazoline derivatives, and preparation method and application thereof

The invention discloses novel 4-substituted anilinoquinazoline derivatives or pharmaceutically acceptable salts thereof, or polymorphic substances, solvates or stereomers of the 4-substituted anilinoquinazoline derivatives, and a preparation method and application thereof. The 4-substituted anilinoquinazoline compounds have favorable inhibition activities for EGFR and VEGFR-2 in a biological test and have obvious effects in an in-vitro anti-human tumor cell proliferation activity test.

CONJUGATES FOR TREATING DISEASES

The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.

Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.

The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.

Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.

3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors

This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.