N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

Base Information

Chemical Name:N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide
CAS No.:1201788-13-7
Molecular Formula:C₂₃H₁₈FN₅O₃S
Molecular Weight:463.492
Hs Code.:

Synonyms:N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

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Chemical Property of N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

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Technology Process of N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

There total 5 articles about N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201788-15-9
N-(4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyphenyl)methanesulfonamide

: 1201788-13-7
N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1201786-84-6
3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201788-13-7
N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Sealed tube

4.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation; Sealed tube

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

With n-butyllithium; lithium hydroxide monohydrate; water; sodium hydride; caesium carbonate; triethylamine; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1201787-19-0
3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridine

: 1201788-13-7
N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Sealed tube

3.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation; Sealed tube

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

With n-butyllithium; lithium hydroxide monohydrate; water; caesium carbonate; triethylamine; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;