4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

Base Information

Chemical Name:4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline
CAS No.:1201788-14-8
Molecular Formula:C₂₉H₂₂FN₅O₃S
Molecular Weight:539.59
Hs Code.:

Synonyms:4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

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Chemical Property of 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

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Technology Process of 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

There total 4 articles about 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 461699-81-0
2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1201787-20-3
3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201788-14-8
4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 125 ℃; for 1h; Microwave irradiation; Sealed tube;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1201788-14-8
4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Sealed tube

With n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 1201786-84-6
3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201788-14-8
4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation; Sealed tube

With n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide;