(benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Base Information

Chemical Name:(benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester
CAS No.:853030-27-0
Molecular Formula:C₃₁H₃₂NO₅P
Molecular Weight:529.573
Hs Code.:

Synonyms:(benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

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Chemical Property of (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

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Technology Process of (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

There total 5 articles about (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 104-53-0
3-phenyl-propionaldehyde

: 161084-48-6
benzyl (N-benzyloxycarbonylamino)benzylphosphinite

: 853030-27-0
(benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Guidance literature:: With chloro-trimethyl-silane; triethylamine; In dichloromethane; for 24h;
DOI:10.1016/j.tetlet.2005.03.083

Reference yield:

: 115752-21-1
α-(Diphenylmethylamino)benzylphosphonous acid

: 853030-27-0
(benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. HBr / 1 h / Heating

2: H₂O; dioxane / 24 h / pH 10

3: DCC; DMAP / tetrahydrofuran / 4 h

4: 86 percent / Et₃N; trimethylsilyl chloride / CH₂Cl₂ / 24 h

With dmap; chloro-trimethyl-silane; hydrogen bromide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tetlet.2005.03.083

Reference yield:

: 126529-62-2
1-amino-1-phenylmethylphosphinic acid

: 853030-27-0
(benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂O; dioxane / 24 h / pH 10

2: DCC; DMAP / tetrahydrofuran / 4 h

3: 86 percent / Et₃N; trimethylsilyl chloride / CH₂Cl₂ / 24 h

With dmap; chloro-trimethyl-silane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tetlet.2005.03.083