115752-21-1

Upstream product

• 62506-88-1 N-benzylidenediphenylmethanamine 
• 100-52-7 benzaldehyde 

Downstream Products

• 126529-62-2 1-amino-1-phenylmethylphosphinic acid 
• 162931-86-4 (R)-(+)-N-benzyloxycarbonyl-1-amino-1-phenylmethylphosphinic acid 
• 161084-48-6 benzyl (N-benzyloxycarbonylamino)benzylphosphinite 
• 853030-27-0 (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester 
• 853030-28-1 (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-pentyl)-phosphinic acid benzyl ester 
• 853030-26-9 (benzyloxycarbonylamino-phenyl-methyl)-(hydroxy-phenyl-methyl)-phosphinic acid benzyl ester 
• 853030-25-8 (benzyloxycarbonylamino-phenyl-methyl)-(1-trimethylsilanyloxy-ethyl)-phosphinic acid ethyl ester 
• 853030-32-7 (benzyloxycarbonylamino-phenyl-methyl)-phosphinic acid ethyl ester 
• 106019-40-3 α-(N-benzyloxycarbonylamino)benzyl-H-phosphonous acid 
• 918329-87-0 (benzyloxycarbonylamino-phenyl-methyl)-[1-(trityl-amino)-butyl]-phosphinic acid methyl ester 
• 918329-99-4 (benzyloxycarbonylamino-phenyl-methyl)-phosphinic acid methyl ester 

Relevant academic research and scientific papers

AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN

The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(═O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(═O)—O—C(R8)(R9)—OC(═O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(═O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR18, —CHR19—OC(═O)OR20 and —CHR19—OC(═O)OR20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more advantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.

Facile synthesis of bis-α-aminoalkylphosphinates

Herein we report a facile synthesis of esters of bis-α- aminoalkylphosphinic acids obtained by an addition of Cbz-protected phosphinic analogues of amino acid methyl esters to an appropriate imine in refluxing benzene. Complete deprotection of the esters

Synthesis of α1-(Cbz-aminoalkyl)-α2- (hydroxyalkyl)phosphinic esters

A synthesis of α1-(Cbz-aminoalkyl)-α2- (hydroxyalkyl)phosphinic esters was achieved by the 1,2-addition of the appropriate aldehyde to Cbz-protected phosphinic analogues of amino acid esters in the presence of at least three equivale

A New Synthetic Route to 1-Aminoalkylphosphonous Acids

The addition of bis(trimethylsilyl) phosphonite to N-(diphenylmethyl)imines 1 yields bis(trimethylsilyl) 1-(diphenylmethylamino)alkylphosphonites 2, which can be easily converted into 1-(diphenylmethylamino)alkylphosphonous acids 3 by treatment with aqueo