126529-62-2

Upstream product

• 115752-21-1 α-(Diphenylmethylamino)benzylphosphonous acid 
• 6907-68-2 N-[phenyl(acetylamino)methyl]acetamide 
• 100-52-7 benzaldehyde 
• 38662-28-1 N-Benzylidene-1-Phenyl- 1,1-Diphenylmethanamine 
• 62506-88-1 N-benzylidenediphenylmethanamine 
• 932-90-1 Benzaldoxime 

Downstream Products

• 106019-40-3 α-(N-benzyloxycarbonylamino)benzyl-H-phosphonous acid 
• 137957-81-4 Bis(aminobenzyl)phosphinsaeure Hydrochlorid 
• 64760-70-9 N-ethyl α-amino benzylphosphonic acid 
• 25881-35-0 (R,S)-<α-(Benzylamino)benzyl>phosphonsaeure 
• 918329-87-0 (benzyloxycarbonylamino-phenyl-methyl)-[1-(trityl-amino)-butyl]-phosphinic acid methyl ester 
• 918329-99-4 (benzyloxycarbonylamino-phenyl-methyl)-phosphinic acid methyl ester 
• 161084-48-6 benzyl (N-benzyloxycarbonylamino)benzylphosphinite 
• 853030-27-0 (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-3-phenyl-propyl)-phosphinic acid benzyl ester 
• 853030-28-1 (benzyloxycarbonylamino-phenyl-methyl)-(1-hydroxy-pentyl)-phosphinic acid benzyl ester 
• 853030-26-9 (benzyloxycarbonylamino-phenyl-methyl)-(hydroxy-phenyl-methyl)-phosphinic acid benzyl ester 
• 853030-25-8 (benzyloxycarbonylamino-phenyl-methyl)-(1-trimethylsilanyloxy-ethyl)-phosphinic acid ethyl ester 
• 853030-32-7 (benzyloxycarbonylamino-phenyl-methyl)-phosphinic acid ethyl ester 

Relevant academic research and scientific papers

AMINOPHOSPHINIC DERIVATIVES THAT CAN BE USED IN THE TREATMENT OF PAIN

The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(═O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(═O)—O—C(R8)(R9)—OC(═O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(═O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR18, —CHR19—OC(═O)OR20 and —CHR19—OC(═O)OR20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more advantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.

Facile synthesis of bis-α-aminoalkylphosphinates

Herein we report a facile synthesis of esters of bis-α- aminoalkylphosphinic acids obtained by an addition of Cbz-protected phosphinic analogues of amino acid methyl esters to an appropriate imine in refluxing benzene. Complete deprotection of the esters

Synthesis of α1-(Cbz-aminoalkyl)-α2- (hydroxyalkyl)phosphinic esters

A synthesis of α1-(Cbz-aminoalkyl)-α2- (hydroxyalkyl)phosphinic esters was achieved by the 1,2-addition of the appropriate aldehyde to Cbz-protected phosphinic analogues of amino acid esters in the presence of at least three equivale

(α-aminophosphino) peptide derivatives, method for making same and therapeutic applications thereof

The invention concerns compounds derived from (α-aminophosphino) peptides, of general formula (I), in which R1and R2each represents a hydrogen atom or taken together form an imine with the adjacent nitrogen atom; R3represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally, a methyl group substituted by a heterocyclic, aromatic or saturated group; R4represents a phenyl group, a benzyl group, these groups capable of being substituted or not, a hydrogen atom, an alkyl group, analkenyl group or a cycloalkyl group; R5represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl, cycloalkylmethyl group or finally a methyl group substituted by a heterocyclic, aromatic or saturated group; R6, R7and R8can in particular represent a hydrogen atom, an alkyl group, a phenyl group substituted or not . . . n is equal to 0 or 1, in the form of enantiomers, diastereoisomers or racemic mixtures, their salts, their method of preparation and their therapeutic applications.

Synthesis of phosphinic and phosphonic analogs of aromatic amino acids

The reaction of aryl and aralkyl aldoximes with hypophosphorous acid resulted in aminophosphinic acids, which were oxidized into the corresponding aminophosphonic acids.

Multiple solid phase synthesis of (RS)-1-aminophosphinic acids

Novel resin bound (RS)-1-aminophosphinic acids, prepared by the facile addition of bis(trimethylsilyl)phosphonite to 9-aryl or alkylimino-xanthen-3-yloxymethyl polystyrene, on acidolysis afforded (RS)-1-aminophosphinic acids in high yields and purities.

A novel synthetic route to 1-aminoalkylphosphinic acids

A 'one-pot' synthesis of various 1-aminoalkylphosphinic acids is described. They were obtained in high yield by the deprotection of the corresponding bis(trimethylsilyl) N-tritylaminoalkylphosphites. The latter were prepared by addition of bis(trimethylsilyl) phosphonite to a N-tritylalkanimine.

SYNTHESIS OF AMINOBENZYLPHOSPHONOUS ACIDS VIA DIRECT AMIDOALKYLATION OF HYPOPHOSPHOROUS ACID

Aminobenzylphosphonic acids are obtained by amidoalkylation of hypophosphorous acid with N,N'-arylidene bisamides.Key words: Aminobenzylphosphonous acid; amidoalkylation; hypophosphorous acid; N,N'-arylidene bisamides.