3-(p-tolyloxy)-2,5-dibromothiophene

Base Information

• Chemical Name: 3-(p-tolyloxy)-2,5-dibromothiophene
• CAS No.: 866824-52-4
• Molecular Formula: C₁₁H₈Br₂OS
• Molecular Weight: 348.058
• Mol file: 866824-52-4.mol

Synonyms:3-(p-tolyloxy)-2,5-dibromothiophene

Chemical Property of 3-(p-tolyloxy)-2,5-dibromothiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(p-tolyloxy)-2,5-dibromothiophene

There total 1 articles about 3-(p-tolyloxy)-2,5-dibromothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-(p-tolyloxy)thiophene (42057-01-2) → 3-(p-tolyloxy)-2,5-dibromothiophene (866824-52-4) + 3-(4-(bromomethyl)phenoxy)-2,5-dibromothiophene

Guidance literature:

With bromine; acetic acid; In chloroform; Heating;

DOI:10.1039/b502164b

Reference yield: 40.0%

3-(p-tolyloxy)-2,5-dibromothiophene (866824-52-4) → 3-(p-tolyloxy)-2-bromothiophene + 4-(p-tolyloxy)-2-bromothiophene (866824-53-5)

Guidance literature:

With n-butyllithium; In diethyl ether; at -78 ℃; for 1h;

DOI:10.1039/b502164b

Reference yield:

3-(p-tolyloxy)-2,5-dibromothiophene (866824-52-4) → 3-(p-tolyloxy)-2-(thiophen-2-yl)thiophene

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / n-BuLi / diethyl ether / 1 h / -78 °C

2: 65 percent / Pd(PPh₃)4 / toluene / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; In diethyl ether; toluene; 2: Stille coupling;

DOI:10.1039/b502164b

upstream raw materials:

3-(p-tolyloxy)thiophene

Downstream raw materials:

4-(p-tolyloxy)-2-bromothiophene

4-(p-tolyloxy)-2-(4-(p-tolyloxy)thiophen-2-yl)thiophene