4-(p-tolyloxy)-2-bromothiophene

Base Information

• Chemical Name: 4-(p-tolyloxy)-2-bromothiophene
• CAS No.: 866824-53-5
• Molecular Formula: C₁₁H₉BrOS
• Molecular Weight: 269.162
• Mol file: 866824-53-5.mol

Synonyms:4-(p-tolyloxy)-2-bromothiophene

Chemical Property of 4-(p-tolyloxy)-2-bromothiophene

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(p-tolyloxy)-2-bromothiophene

There total 2 articles about 4-(p-tolyloxy)-2-bromothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-(p-tolyloxy)-2,5-dibromothiophene (866824-52-4) → 3-(p-tolyloxy)-2-bromothiophene + 4-(p-tolyloxy)-2-bromothiophene (866824-53-5)

Guidance literature:

With n-butyllithium; In diethyl ether; at -78 ℃; for 1h;

DOI:10.1039/b502164b

Reference yield:

3-(p-tolyloxy)thiophene (42057-01-2) → 4-(p-tolyloxy)-2-bromothiophene (866824-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Br₂; AcOH / CHCl₃ / Heating

2: 40 percent / n-BuLi / diethyl ether / 1 h / -78 °C

With n-butyllithium; bromine; acetic acid; In diethyl ether; chloroform;

DOI:10.1039/b502164b

Reference yield: 20.0%

4-(p-tolyloxy)-2-bromothiophene (866824-53-5) → 4-(p-tolyloxy)-2-(4-(p-tolyloxy)thiophen-2-yl)thiophene (866824-50-2)

Guidance literature:

4-(p-tolyloxy)-2-bromothiophene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.5h;

With tributyltin chloride; In diethyl ether; at -78 - 20 ℃;

With palladium diacetate; copper dichloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/b502164b

upstream raw materials:

3-(p-tolyloxy)-2,5-dibromothiophene

3-(p-tolyloxy)thiophene

Downstream raw materials:

4-(p-tolyloxy)-2-(4-(p-tolyloxy)thiophen-2-yl)thiophene