5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide

Base Information

Chemical Name:5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide
CAS No.:857355-32-9
Molecular Formula:C₁₆H₁₅ClN₄O₂
Molecular Weight:330.774
Hs Code.:

Synonyms:5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide

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Chemical Property of 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide

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Technology Process of 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide

There total 1 articles about 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

: 623155-19-1
3-amino-N-cyclopropyl-4-methylbenzamide

: 34604-60-9
5-hydroxypyrazinoic acid

: 857355-32-9
5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide

Guidance literature:: 5-hydroxypyrazinoic acid; With phosphorus pentachloride; trichlorophosphate; at 100 ℃; for 16h;

3-amino-N-cyclopropyl-4-methylbenzamide; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 20.0%

: 586-98-1
2-Hydroxymethylpyridine

: 857355-32-9
5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide

: N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-(pyridin-2-ylmethoxy)pyrazine-2-carboxamide

Guidance literature:: 2-Hydroxymethylpyridine; With sodium hydride; at 20 ℃; for 0.166667h;

5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide; With 1-methyl-pyrrolidin-2-one; for 48h;