(R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Base Information

Chemical Name:(R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine
CAS No.:210834-60-9
Molecular Formula:C₁₇H₂₂O₄S
Molecular Weight:322.425
Hs Code.:

Synonyms:(R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Suppliers and Price of (R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Chemical Property:

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Technology Process of (R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

There total 1 articles about (R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 116511-95-6
(benzenesulfonyl)methyllithium

: 181771-83-5
(R)-8a-(2-Iodo-ethyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

: 210834-60-9
(R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Guidance literature:: DOI:10.1016/S0040-4039(98)00860-0

Reference yield: 70.0%

: 210834-57-4
3-((1R,2S)-2-Cyano-1-methyl-5-oxo-cyclopentyl)-propionic acid methyl ester

: 210834-60-9
(R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

: 210834-61-0
(1S,2R)-2-((R)-4-Benzenesulfonyl-3-oxo-6-4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl-hexyl)-2-methyl-3-oxo-cyclopentanecarbonitrile

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1016/S0040-4039(98)00860-0

Reference yield:

: 210834-60-9
(R)-8a-(3-Benzenesulfonyl-propyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

: C₂₇H₃₁NO₃S

Guidance literature:: Multi-step reaction with 10 steps

1: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

2: SmI₂ / tetrahydrofuran / 0 °C

3: dimethylformamide / 80 °C

4: TBAF, SiO₂ / CHCl₃

5: KHMDS / tetrahydrofuran / -78 °C

6: TBAF / tetrahydrofuran

7: KHMDS / tetrahydrofuran / -78 °C

8: KHMDS / tetrahydrofuran / -78 °C

9: TBAF / tetrahydrofuran

10: 70 percent / KOAc, DMA / 10percent Pd(dppb) / 75 °C

With n-butyllithium; samarium diiodide; tetrabutyl ammonium fluoride; potassium acetate; silica gel; potassium hexamethylsilazane; 2,4-dichlorophenoxyacetic acid dimethylamine; Pd(dppb); In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00860-0