(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Name:(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1466566-15-3
Molecular Formula:C₂₉H₂₈N₆O₂Si
Molecular Weight:520.666
Hs Code.:

Synonyms:(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 8 articles about (S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1466563-97-2
C₂₄H₁₉ClN₆O₂

: 1066-54-2
trimethylsilylacetylene

: 1466566-15-3
(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With trans-bis(acetonitrile)palladium(II) chloride; caesium carbonate; XPhos; at 22 - 75 ℃; for 2.83333h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.6b00238

Reference yield:

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

: 1466566-15-3
(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.03 h / 20 °C

1.2: 22 h

1.3: 0.5 h / 20 °C

2.1: dichloro bis(acetonitrile) palladium(II); XPhos; caesium carbonate / acetonitrile / 14.75 h / 75 - 85 °C / Sealed tube; Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; XPhos; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1383056-73-2
2-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1466566-15-3
(S)-2-amino-N-(1-(1-oxo-2-phenyl-8-((trimethylsilyl)ethynyl)-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.03 h / 20 °C

1.2: 22 h

1.3: 0.5 h / 20 °C

2.1: dichloro bis(acetonitrile) palladium(II); XPhos; caesium carbonate / acetonitrile / 14.75 h / 75 - 85 °C / Sealed tube; Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; XPhos; In N,N-dimethyl-formamide; acetonitrile;