3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

Base Information

Chemical Name:3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid
CAS No.:1201663-80-0
Molecular Formula:C₂₇H₂₀Cl₂FNO₅S
Molecular Weight:560.43
Hs Code.:

Synonyms:3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

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Chemical Property of 3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

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Technology Process of 3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

There total 6 articles about 3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1201663-81-1
3-chloro-5-(chlorosulfonyl)-4-hydroxybenzoic acid

: 1201663-79-7
1-(4'-chlorobiphenyl-3-yl)-N-(4-fluorobenzyl)methanamine

: 1201663-80-0
3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

Guidance literature:: 3-chloro-5-(chlorosulfonyl)-4-hydroxybenzoic acid; 1-(4'-chlorobiphenyl-3-yl)-N-(4-fluorobenzyl)methanamine; With triethylamine; In dichloromethane; at 20 ℃; for 18.5h; Inert atmosphere;

With triethylamine; In dichloromethane; at 40 ℃; for 6h;

With hydrogenchloride; In water; pH=1 - 2;

Reference yield:

: 1172338-38-3
(4'-chlorobiphenyl-3-yl)methanamine hydrochloride

: 1201663-80-0
3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; isopropyl alcohol / 1 h / 20 °C

1.2: 3 h / 20 °C / Inert atmosphere

1.3: 0.17 h

2.1: triethylamine / dichloromethane / 18.5 h / 20 °C / Inert atmosphere

2.2: 6 h / 40 °C

2.3: pH 1 - 2

With triethylamine; In dichloromethane; isopropyl alcohol;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1201663-80-0
3-chloro-5-(N-((4'-chlorobiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)sulfamoyl)-4-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: chlorosulfonic acid / 2 h / 65 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 18.5 h / 20 °C / Inert atmosphere

2.2: 6 h / 40 °C

2.3: pH 1 - 2

With chlorosulfonic acid; triethylamine; In dichloromethane;