Technology Process of (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol
There total 5 articles about (S)-p-tolyl(p-(trifluoromethyl)phenyl)methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tri(4-tolyl)boroxine;
With
diethylzinc;
In
toluene;
at 60 ℃;
for 0.5h;
4-Trifluoromethylbenzaldehyde;
In
toluene;
at 0 ℃;
for 0.5h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1002/anie.200703103
- Guidance literature:
-
With
triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether;
at 20 ℃;
for 20h;
Schlenk technique;
DOI:10.1021/jacs.0c04725
- Guidance literature:
-
Multi-step reaction with 4 steps
1: magnesium sulfate; manganese(IV) oxide / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: tetrakis[(S)-5,5'-diphenyl-1,1'-spirobiindanyl-7,7'-diylphosphate] dirhodium (II) / dichloromethane / 0.05 h / 0 °C / Schlenk technique; Inert atmosphere
3: acetic acid; boron trifluoride / dichloromethane / 4 h / 0 °C / Inert atmosphere; Reflux; Schlenk technique
4: 3-chloro-benzenecarboperoxoic acid; triethylamine / diethyl ether / 20 h / 20 °C / Schlenk technique
With
manganese(IV) oxide; boron trifluoride; tetrakis[(S)-5,5'-diphenyl-1,1'-spirobiindanyl-7,7'-diylphosphate] dirhodium (II); magnesium sulfate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane;
DOI:10.1021/jacs.0c04725