21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

Base Information

Chemical Name:21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione
CAS No.:1451396-66-9
Molecular Formula:C₂₈H₃₇BrO₅
Molecular Weight:533.503
Hs Code.:

Synonyms:21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

Suppliers and Price of 21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Technology Process of 21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

There total 8 articles about 21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 917480-17-2
16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione[11β,16α(R)]

: 1451396-66-9
21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

Guidance literature:: With lithium bromide; In N,N-dimethyl-formamide; at 60 ℃; for 3h;
DOI:10.1016/j.bmcl.2021.128052

Reference yield:

: 204444-44-0
16α,17-[(R,S)-cyclohexylmethylenedioxy]-11β,21-dihydroxypregna-1,4-dien-3,20-dione

: 1451396-66-9
21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In acetonitrile; at 2 - 12 ℃; Inert atmosphere;

Reference yield:

: 204444-44-0
16α,17-[(R,S)-cyclohexylmethylenedioxy]-11β,21-dihydroxypregna-1,4-dien-3,20-dione

: 1451396-73-8
21-bromo-16α,17-[(S)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

: 1451396-66-9
21-bromo-16α,17-[(R)-cyclohexylmethylenedioxy]-11β-hydroxypregna-1,4-dien-3,20-dione

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 10 - 16 ℃; for 1h; Temperature; Time; Inert atmosphere;