16alpha-Hydroxyprednisolone

Base Information Edit

Chemical Name:16alpha-Hydroxyprednisolone
CAS No.:13951-70-7
Molecular Formula:C21H28O6
Molecular Weight:376.45
Hs Code.:2937210000
European Community (EC) Number:237-731-1
UNII:SW97540DC2
DSSTox Substance ID:DTXSID20930496
Nikkaji Number:J216.788C
Wikidata:Q27289433
ChEMBL ID:CHEMBL3542319
Mol file:13951-70-7.mol

Synonyms:13951-70-7;16alpha-Hydroxyprednisolone;16|A-Hydroxyprednisolone;EINECS 237-731-1;UNII-SW97540DC2;11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;SW97540DC2;C21H28O6;11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione;EC 237-731-1;Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11b,16a)-;11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione (16alpha-Hydroxyprednisolone);Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11.beta.,16.alpha.)-;OH-PRED;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;(11beta,16alpha)-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;DTXSID20930496;MFCD00872019;Budesonide Imp. A (EP);Budesonide Impurity A;16|A-hydroxy-prednisolone;11?,16?,17?,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16alpha-Hydroxy-prednisonlone;SCHEMBL145096;16A-HYDROXY-PREDNISOLONE;CHEMBL3542319;Pregna-1,4-diene-3,20-dione, 11.beta.,16.alpha.,17,21-tetrahydroxy-;SEKYBDYVXDAYPY-ILNISADRSA-N;BCP04133;AC1111;16.ALPHA.-HYDROXYPREDNISOLONE;AKOS025286083;BCP9000061;BCP0726000097;BUDESONIDE IMPURITY A [EP IMPURITY];HY-117580;CS-0066553;A807552;Q-101381;Q27289433;(11?,16?)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11beta,16alpha)-;(9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Suppliers and Price of 16alpha-Hydroxyprednisolone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
16a-Hydroxyprednisolone
10g
$ 425.00

TRC
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
50g
$ 760.00

TRC
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
100g
$ 1210.00

TRC
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
25g
$ 485.00

TRC
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
10g
$ 295.00

TRC
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
500mg
$ 245.00

TRC
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
50mg
$ 145.00

ChemScene
16α-Hydroxyprednisolone
100mg
$ 50.00

Chemenu
16alpha-Hydroxyprednisolone 97%
25g
$ 365.00

Chemenu
16alpha-Hydroxyprednisolone 97%
10g
$ 204.00

Total 165 raw suppliers

Chemical Property of 16alpha-Hydroxyprednisolone Edit

Chemical Property:

Appearance/Colour:white crystalline solid
Vapor Pressure:1.86E-16mmHg at 25°C
Melting Point:235-238 °C
Refractive Index:1.629
Boiling Point:591.5 °C at 760 mmHg
PKA:11.93±0.70(Predicted)
Flash Point:325.6 °C
PSA：115.06000
Density:1.381 g/cm³
LogP:0.52840
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
Water Solubility.:815mg/L at 20℃
XLogP3:1.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:376.18858861
Heavy Atom Count:27
Complexity:756

Purity/Quality:

99%+ ^*data from raw suppliers

16a-Hydroxyprednisolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CC(C3C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC34C)O
Isomeric SMILES:C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@]34C)O
Uses A metabolite of Budesonide, an antiinflammatory agent A metabolite of Budesonide (B689490), an antiinflammatory agent. 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Technology Process of 16alpha-Hydroxyprednisolone

There total 19 articles about 16alpha-Hydroxyprednisolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 86401-80-1
11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate

: 13951-70-7
desonide

Guidance literature:: With sodium hydroxide; In methanol; dichloromethane; at 0 - 5 ℃; for 1h; Inert atmosphere;

Reference yield: 93.1%

: C₂₄H₃₀O₈

: 13951-70-7
desonide

Guidance literature:: With potassium carbonate; In ethanol; dichloromethane; at 5 - 10 ℃; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;