8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

Base Information

Chemical Name:8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one
CAS No.:1303952-82-0
Molecular Formula:C₁₉H₂₀F₂N₄O₂
Molecular Weight:374.39
Hs Code.:

Synonyms:8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

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Chemical Property of 8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

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Technology Process of 8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

There total 4 articles about 8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2713-33-9
3,4-difluorophenol

: 1303954-15-5
2-chloro-8-cyclopentyl-1-propyl-1,7-dihydro-purin-6-one

: 1303952-82-0
8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

Guidance literature:: With 1-methyl-pyrrolidin-2-one; potassium carbonate; at 130 ℃; for 12h;
DOI:10.1016/j.bmc.2017.02.029

Reference yield:

: 152529-70-9
Cyclopentane carboxylic acid (6-amino-2,4-dioxo-3-propyl-1,2,3,4-tetra hydro-pyrimidin-5-yl)-amide

: 1303952-82-0
8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentachloride; trichlorophosphate / Reflux

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 130 °C

With phosphorus pentachloride; potassium carbonate; trichlorophosphate; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 3400-45-1
cyclopentanecarboxylic acid

: 1303952-82-0
8-Cyclopentyl-2-(3,4-difluoro-phenoxy)-1-propyl-1,7-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 0 - 20 °C

2: phosphorus pentachloride; trichlorophosphate / Reflux

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 130 °C

With phosphorus pentachloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; methanol;