N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine

Base Information

• Chemical Name: N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine
• CAS No.: 1609963-63-4
• Molecular Formula: C₂₄H₂₃FN₄O₂S
• Molecular Weight: 450.537

Synonyms:N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine

Chemical Property of N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine

Chemical Property:

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Technology Process of N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine

There total 3 articles about N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

dimethylsulfoximine (1520-31-6) + N-(2-benzyloxy-4-fluorophenyl)-7-bromo-5-fluoroquinazolin-4-amine → N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-amine (1609963-63-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In 1,4-dioxane; at 80 ℃; for 4.5h;

Reference yield:

C11H12BrN3 (1609962-88-0) → N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-amine (1609963-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 4.5 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In 1,4-dioxane; acetic acid;

Reference yield:

2-(benzyloxy)-4-fluoroaniline (159471-73-5) → N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-amine (1609963-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 4.5 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In 1,4-dioxane; acetic acid;

upstream raw materials:

C₁₁H₁₂BrN₃

2-(benzyloxy)-4-fluoroaniline

dimethylsulfoximine

Downstream raw materials:

2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol

tert-butyl 4-[2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluorophenoxy]isoxazolidine-2-carboxylate trifluoroacetic acid

C₂₀H₂₂FN₅O₃S

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