(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

Base Information

Chemical Name:(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide
CAS No.:184354-37-8
Molecular Formula:C₁₃H₁₉NO₃
Molecular Weight:237.299
Hs Code.:

Synonyms:(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

Chemical Property:

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Technology Process of (2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

There total 3 articles about (2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 134440-87-2
(2'R,3'S,4R,5S)-3-(3'-hydroxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one

: 77943-39-6
4-methyl-5-phenyloxazolidin-2-one

: 184354-37-8
(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

Guidance literature:: With trimethylaluminum; In dichloromethane; at 0 - 4 ℃; for 3h;
DOI:10.1021/jo982145i

Reference yield:

: 1217320-21-2
C₂₀H₂₁NO₂S₂

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 184354-37-8
(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/b920193a

Reference yield:

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 134440-87-2
(2'R,3'S,4R,5S)-3-(3'-hydroxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one

: 184354-37-8
(2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide

Guidance literature:: With trimethylaluminum; Yield given. Multistep reaction; 1.) THF, hexane, 0 deg C, 30 min, 2.) THF, hexane, 1 h;
DOI:10.1021/ja961683e