3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

Base Information

Chemical Name:3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid
CAS No.:1332706-65-6
Molecular Formula:C₂₄H₁₉ClN₂O₃
Molecular Weight:418.879
Hs Code.:

Synonyms:3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

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Chemical Property of 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

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Technology Process of 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

There total 10 articles about 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332706-96-3
ethyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

: 1332706-65-6
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

Guidance literature:: ethyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate; With potassium hydrogensulfate; formic acid; In water; at 80 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 335349-57-0
2-nitro-4-iodo-5-chloroaniline

: 1332706-65-6
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 3 h / Reflux

3: potassium carbonate / acetone / 0 - 20 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 80 °C

8: formic acid; potassium hydrogensulfate / water / 1 h / 80 °C

With potassium phosphate; potassium hydrogensulfate; formic acid; iron; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 1332706-65-6
3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid; N-iodo-succinimide / 50 °C

2: ammonium chloride; iron / ethanol; water / 50 °C / Inert atmosphere

3: potassium hydroxide / ethanol / 3 h / Reflux

4: potassium carbonate / acetone / 0 - 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 20 °C

6: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 80 °C

9: formic acid; potassium hydrogensulfate / water / 1 h / 80 °C

With potassium phosphate; potassium hydrogensulfate; N-iodo-succinimide; formic acid; iron; potassium carbonate; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;