ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE
• CAS No.: 87121-89-9
• Molecular Formula: C7H10O3
• Molecular Weight: 142.155
• Hs Code.: 2918300090
• Mol file: 87121-89-9.mol

Synonyms:3-Oxo-cyclobutanecarboxylic acid ethyl ester

Chemical Property of ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.231mmHg at 25°C
• Refractive Index: 1.473
• Boiling Point: 206.9 °C at 760 mmHg
• Flash Point: 82.3 °C
• PSA: 35.53000
• Density: 1.169 g/cm³
• LogP: 0.19590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.0% ^*data from raw suppliers

Ethyl 3-oxocyclobutanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 3-oxocyclobutanecarboxylate is used as pharmaceutical intermediate.

Technology Process of ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE

There total 11 articles about ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl trans-3-hydroxycyclobutanecarboxylate (17205-02-6) → ethyl 3-oxocyclobutanecarboxylate (87121-89-9)

Guidance literature:

ethyl trans-3-hydroxycyclobutanecarboxylate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

Reference yield: 93.5%

3-oxocyclobutanecarboxylic acid (23761-23-1) + Triethyl orthoacetate (78-39-7) → ethyl 3-oxocyclobutanecarboxylate (87121-89-9)

Guidance literature:

In toluene; for 5h; Time; Reflux;

Reference yield: 82.0%

ethanol (64-17-5) + 3-oxocyclobutanecarboxylic acid (23761-23-1) → ethyl 3-oxocyclobutanecarboxylate (87121-89-9)

Guidance literature:

With hydrogenchloride; at -78 - 20 ℃; for 18h;

upstream raw materials:

ethyl trans-3-hydroxycyclobutanecarboxylate

3-oxocyclobutanecarboxylic acid

Triethyl orthoacetate

3-benzyloxy-cyclobutanecarboxylic acid ethyl ester

Downstream raw materials:

cis-3-phenylcyclobutanecarboxylic acid

(1s,3s)-3-(4-fluorophenyl)cyclobutanecarboxylic acid

cis-3-(m-Tolyl)-cyclobutancarbonsaeure

cis-3-Phenyl-cyclobutancarbonsaeure-aethylester