Chemical Property of Nisoldipine
Chemical Property:
- Appearance/Colour:light tan crystals
- Vapor Pressure:2.95E-10mmHg at 25°C
- Melting Point:147-148 °C
- Refractive Index:1.544
- Boiling Point:503.3 °C at 760 mmHg
- PKA:2.67±0.70(Predicted)
- Flash Point:258.2 °C
- PSA：110.45000
- Density:1.205 g/cm3
- LogP:4.05380
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO: >10mg/mL
- XLogP3:3.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:7
- Exact Mass:388.16343649
- Heavy Atom Count:28
- Complexity:704
- Purity/Quality:
-
99.0% *data from raw suppliers
Nisoldipine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
20/21/22
- Safety Statements:
36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Cardiovascular Agents
- Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
- Recent ClinicalTrials:Single-Dose Fed Bioequivalence Study of Nisoldipine Extended-Release Tablets (40 mg; Mylan) and Sular? Extended-Release Tablets (40 mg; First Horizon) in Healthy Volunteers
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Description
Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
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Uses
Dihydropyridine calcium channel blocker. Antihypertensive and antianginal urease inhibitor Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
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Therapeutic Function
Coronary vasodilator
