(3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

Base Information

Chemical Name:(3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone
CAS No.:1354946-40-9
Molecular Formula:C₁₆H₁₉F₃N₆O
Molecular Weight:368.362
Hs Code.:

Synonyms:(3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

Chemical Property:

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Technology Process of (3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

There total 2 articles about (3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354947-67-3
(3R)-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

: 75-03-6
ethyl iodide

: 1354946-40-9
(3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 922178-61-8
?(R)-3-methylpiperazin-2-one

: 1094265-93-6
5-(chloromethyl)-1-[4-(trifluoromethyl)phenyl]-1H-tetrazole

: 1354946-40-9
(3R)-1-ethyl-3-methyl-4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-piperazinone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 0.33 h / 120 °C

2: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; acetonitrile;