Technology Process of 3-(3,4-dichlorophenyl)prop-2-yn-1-yl 2-bromo-2,2-difluoroacetate
There total 2 articles about 3-(3,4-dichlorophenyl)prop-2-yn-1-yl 2-bromo-2,2-difluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bromodifluoroacetic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 2h;
Sealed tube;
3-(3,4-dichlorophenyl)prop-2-yn-1-ol;
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
Sealed tube;
DOI:10.1021/acs.orglett.5b01027
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / -10 - 20 °C / Schlenk technique; Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Sealed tube
2.2: 0 - 20 °C / Sealed tube
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.5b01027
- Guidance literature:
-
With
potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; sodium 2-bromo-2,2-difluoro-acetate;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 14h;
Inert atmosphere;
DOI:10.1021/acs.orglett.5b01027
