215715-41-6

Upstream product

• 621-59-0 isovanillin 
• 34123-66-5 O-isopropylisovanillin 
• 200941-15-7 2-iodo-5-isopropoxy-4-methoxybenzaldehyde 
• 215715-43-8 β,β-dibromo-3-isopropoxy-4-methoxystyrene 
• 215715-44-9 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxybenzaldehyde 
• 215715-45-0 5-isopropoxy-2-[2'-(3''-isopropoxy-4''-methoxyphenyl)ethynyl]-4-methoxyphenol 
• 475232-31-6 formic acid 5-isopropoxy-2-(3-isopropoxy-4-methoxy-phenylethynyl)-4-methoxy-phenyl ester 
• 289507-36-4 2-(2-bromo-4,5-dimethoxyphenyl)ethyl alcohol 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 516465-82-0 (3-isopropoxy-4-methoxyphenyl)boronic acid 

Downstream Products

• 475232-32-7 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 

Relevant academic research and scientific papers

Scalable Total Syntheses of Some Natural and Unnatural Lamellarins: Application of a One-Pot Domino Process for Regioselective Access to the Central 1,2,4-Trisubstituted Pyrrole Core

Short and scalable total syntheses of lamellarin G trimethyl ether, lamellarin D trimethyl ether, lamellarin H, lamellarin ?, dihydrolamellarin ?, and lamellarin U have been realized in four to six linear steps with an overall yield of ≤22%. Highlights of

Regioselective synthesis of 2,4-differentially arylated pyrroles and its application to the synthesis of lamellarins

An efficient method for the synthesis of 2,4-differentially arylated pyrroles has been developed via stepwise palladium-catalyzed Suzuki-Miyaura coupling of N-benzenesulfonyl-4-bromo-2-iodopyrrole with different arylboronic acids. This method has been applied to the new synthesis of the marine natural products lamellarins.

Total synthesis and evaluation of lamellarin α 20-Sulfate analogues

In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin α lamellarin α 13,20-disulfate and H, were synthesized and their activities against HIV-1 integrase and cancer cell ines were compared with those of lamellarin α 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin α does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin α13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. Copyright