2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

Base Information

Chemical Name:2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide
CAS No.:181872-33-3
Molecular Formula:C₂₈H₂₉F₃N₂O₂
Molecular Weight:482.546
Hs Code.:

Synonyms:2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

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Chemical Property of 2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

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Technology Process of 2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

There total 4 articles about 2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 407-25-0
trifluoroacetic anhydride

: 181872-32-2
(R)-2-[(S)-2-(Amino-diphenyl-methyl)-piperidin-1-yl]-2-phenyl-ethanol

: 181872-33-3
2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jo960910s

Reference yield:

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 181872-33-3
2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / LiBr / diethyl ether / 1.5 h / -20 - 20 °C

2: 96 percent / NaBH₄ / methanol / 2.5 h / Ambient temperature

3: 79 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With sodium tetrahydroborate; triethylamine; lithium bromide; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo960910s

Reference yield:

: 591-51-5
phenyllithium

: 181872-33-3
2,2,2-Trifluoro-N-{[(S)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-diphenyl-methyl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / LiBr / diethyl ether / 1.5 h / -20 - 20 °C

2: 96 percent / NaBH₄ / methanol / 2.5 h / Ambient temperature

3: 79 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With sodium tetrahydroborate; triethylamine; lithium bromide; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo960910s