6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

Base Information

Chemical Name:6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile
CAS No.:1365214-48-7
Molecular Formula:C₁₇H₁₂F₃N₅
Molecular Weight:343.311
Hs Code.:

Synonyms:6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

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Chemical Property of 6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

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Technology Process of 6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

There total 8 articles about 6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1365214-47-6
(2R)-1-{3-bromoimidazo[1,2-b]pyridazin-6-yl}-4,4-difluoro-2-(3-fluorophenyl)pyrrolidine

: 1365214-48-7
6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

Guidance literature:: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1223404-92-9
(2R,4R)-tert-butyl 2-(3-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

: 1365214-48-7
6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 0 °C

4.1: potassium fluoride / dimethyl sulfoxide / 6 h / 105 °C

With potassium fluoride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1223404-93-0
(R)-tert-butyl 2-(3-fluorophenyl)-4-oxopyrrolidine-1-carboxylate

: 1365214-48-7
6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.2: 0 °C

3.1: potassium fluoride / dimethyl sulfoxide / 6 h / 105 °C

With potassium fluoride; diethylamino-sulfur trifluoride; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;