Technology Process of {6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl}carbonylurea
There total 10 articles about {6-[(2R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl}carbonylurea which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium fluoride / dimethyl sulfoxide / 6 h / 105 °C
2.1: sodium hydroxide; dihydrogen peroxide / methanol / 0.08 h / 50 °C
3.1: 1,1-dichloroethane / 0.5 h / 90 °C
3.2: 0.17 h / 20 °C
With
potassium fluoride; dihydrogen peroxide; sodium hydroxide;
In
methanol; 1,1-dichloroethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C
2.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3.2: 0 °C
4.1: potassium fluoride / dimethyl sulfoxide / 6 h / 105 °C
5.1: sodium hydroxide; dihydrogen peroxide / methanol / 0.08 h / 50 °C
6.1: 1,1-dichloroethane / 0.5 h / 90 °C
6.2: 0.17 h / 20 °C
With
potassium fluoride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; dihydrogen peroxide; trifluoroacetic acid; sodium hydroxide;
In
methanol; 1,1-dichloroethane; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
2.2: 0 °C
3.1: potassium fluoride / dimethyl sulfoxide / 6 h / 105 °C
4.1: sodium hydroxide; dihydrogen peroxide / methanol / 0.08 h / 50 °C
5.1: 1,1-dichloroethane / 0.5 h / 90 °C
5.2: 0.17 h / 20 °C
With
potassium fluoride; diethylamino-sulfur trifluoride; dihydrogen peroxide; trifluoroacetic acid; sodium hydroxide;
In
methanol; 1,1-dichloroethane; dichloromethane; dimethyl sulfoxide;
