(E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone

Base Information

• Chemical Name: (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone
• CAS No.: 1596368-67-0
• Molecular Formula: C₁₉H₁₇N₅O₅
• Molecular Weight: 395.374
• Mol file: 1596368-67-0.mol

Synonyms:(E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone

Chemical Property of (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone

There total 2 articles about (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(4-nitrophenyl)semicarbazide (17433-93-1) + 7-(N,N-dimethylamino)-2-oxo-2H-chromene-3-carbaldehyde → (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone (1596368-67-0)

Guidance literature:

In ethanol; for 0.25h; Reflux;

DOI:10.1016/j.saa.2014.01.127

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone (1596368-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 18 h / 20 °C / Cooling with ice

2: hydrazine hydrate / 4 h / 20 °C

3: ethanol / 0.25 h / Reflux

With pyridine; hydrazine hydrate; In ethanol; dichloromethane;

DOI:10.1016/j.saa.2014.01.127

upstream raw materials:

4-(4-nitrophenyl)semicarbazide

4-nitro-aniline