17433-93-1

Basic information

• Product Name: 3-Amino-1-(4-nitrophenyl)urea
• Synonyms: 3-Amino-1-(4-nitrophenyl)urea;1-amino-3-(4-nitrophenyl)urea
• CAS NO: 17433-93-1
• Molecular Formula: C₇H₈N₄O₃
• Molecular Weight: 196.17
• Mol File: 17433-93-1.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Amino-1-(4-nitrophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-1-(4-nitrophenyl)urea(17433-93-1)
• EPA Substance Registry System: 3-Amino-1-(4-nitrophenyl)urea(17433-93-1)

Safety Data

• Hazardous Substances Data: 17433-93-1(Hazardous Substances Data)

Upstream product

• 100-28-7 4-Nitrophenyl isocyanate 
• 6465-01-6 (4-nitrophenyl)carbamic acid phenyl ester 
• 100-01-6 4-nitro-aniline 
• 917-61-3 sodium isocyanate 
• 302-01-2 hydrazine 
• 2621-73-0 ethyl 4-nitrophenylcarbamate 
• 51028-38-7 (4-nitro-phenyl)-carbamoyl chloride 
• 2733-41-7 4-nitrobenzoyl azide 
• 17433-87-3 acetone-[4-(4-nitro-phenyl)-semicarbazone] 
• 556-10-5 p-nitrophenylurea 

Downstream Products

• 16249-03-9 Acetophenon-p-nitrophenyl-semicarbazon 
• 16249-18-6 p-Nitro-benzaldehyd-p-nitrophenyl-semicarbazon 
• 16249-16-4 o-Nitro-benzaldehyd-p-nitrophenyl-semicarbazon 
• 278783-69-0 4-(4-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1346911-35-0 3-(4-fluorophenyl)-N-(4-nitrophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide 
• 1346911-38-3 C₂₇H₂₆N₄O₇ 
• 1346911-41-8 3-phenyl-N-(4-nitrophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide 
• 1346911-33-8 C₂₅H₂₁ClN₄O₅ 
• 1346911-45-2 C₂₆H₂₄N₄O₆ 
• 1346911-31-6 3-(pyridin-4-yl)-N-(4-nitrophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide 
• 1596368-67-0 (E)-1-{[(7-dimethylamino)-2-oxo-2H-chromen-3-yl]methylidene}-4-(4-nitrophenyl)semicarbazone 
• 13915-23-6 1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-3-(4-nitro-phenyl)-urea 

Relevant articles and documents

Synthesis, In-vitro evaluation and molecular docking studies of oxoindolin phenylhydrazine carboxamides as potent and selective inhibitors of ectonucleoside triphosphate diphosphohydrolase (NTPDase)

Members of the ectonucleoside triphosphate diphosphohydrolases (NTPDases) constitute the major family of enzymes responsible for the maintenance of extracellular levels of nucleotides and nucleosides by catalyzing the hydrolysis of nucleoside triphosphate

Azobenzene-Semicarbazone Enables Optical Control of Insect Sodium Channels and Behavior

Photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. The application of photopharmacology in the research of invertebrate sodium channels has not been investigated. Here we report several photochromic ligands of metaflumizone. One ligand, termed ABM04, underwent reversible trans-cis isomerization under ultraviolet or blue light irradiation. cis-ABM04 had excellent larvicidal activity against mosquito larvae with an LC50 value of 4.39 μM and showed insecticidal activity against Mythimna separata with an LC50 value of 7.19 μM. However, trans-ABM04 was not found to have biological activity. ABM04 (10 μM) can induce depolarization of dorsal unpaired median neurons and enable the real-time photoregulation of mosquito larval behavior. The precise regulation of invertebrate sodium channels is realized for the first time, which provides a new strategy for the basic and accurate research of invertebrate sodium channels.

Synthesis of N-aryl and N-arylcarbamoylamino derivatives of 1,3-diazinane-5-carboxamide and their activity against glioblastoma LN-229 cell line

Six structural motifs based on the initial (lead) structure of merbarone were designed, prepared, and tested against the glioblastoma LN-229 cell line. Three different structural moieties were modified in the search for optimal glioblastoma activity: the 1,3-diazinane moiety, the aryl moiety, and the heteroatom linker. Calculated molecular descriptors such as lipophilicity (C log P), acidic strength (calculated pKa), and polar surface area (PSA) were used to design a diverse structural library of these compounds. From six different structural motifs and 136 compounds, a handful of examples with moderate (100 μg/ml), good (10 μg/ml) and excellent (1 μg/ml) glioblastoma activity were elucidated.