4'-BROMOSALICYLANILIDE

Base Information

• Chemical Name: 4'-BROMOSALICYLANILIDE
• CAS No.: 2627-77-2
• Molecular Formula: C13H10 Br N O2
• Molecular Weight: 292.132
• Hs Code.: 2924299090
• Mol file: 2627-77-2.mol

Synonyms:Salicylanilide,4'-bromo- (7CI,8CI); 4'-Bromosalicylanilide; 4'-Monobromosalicylanilide; NSC526279; Salicyl-4'-bromoanilide

Chemical Property of 4'-BROMOSALICYLANILIDE

Chemical Property:

• Melting Point: 172 °C
• Boiling Point: 338.3°Cat760mmHg
• PKA: 8.27±0.30(Predicted)
• Flash Point: 158.4°C
• PSA: 49.33000
• Density: 1.597g/cm³
• LogP: 3.48000

Purity/Quality:

98% ^*data from raw suppliers

4'-Bromosalicylanilide >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-BROMOSALICYLANILIDE

There total 4 articles about 4'-BROMOSALICYLANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-bromo-aniline (106-40-1) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → N-(4-bromophenyl)-2-hydroxybenzamide (2627-77-2)

Guidance literature:

With phosphorus trichloride; In 5,5-dimethyl-1,3-cyclohexadiene; for 0.75h; Microwave irradiation;

DOI:10.1080/00397911.2010.481745

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → N-(4-bromophenyl)-2-hydroxybenzamide (2627-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₃ / chlorobenzene / 0.25 h / Heating

2: chlorobenzene / 3 h / Heating

With phosphorus trichloride; In chlorobenzene;

DOI:10.1021/jm00142a023

Reference yield:

4-bromo-aniline (106-40-1) + salicyloyl chloride (1441-87-8) → N-(4-bromophenyl)-2-hydroxybenzamide (2627-77-2)

Guidance literature:

In chlorobenzene; for 3h; Heating;

DOI:10.1021/jm00142a023

upstream raw materials:

4-bromo-aniline

salicyloyl chloride

salicylic acid

Downstream raw materials:

3-(4-Bromophenyl)-2H-1,3-benzoxazine-2,4(3H)-dione

3-(4-bromo-phenyl)-2-methoxycarbonylmethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester

10-(4-bromophenyl)-7-nitrodibenzo[ b,f][1,4]oxazepin-11-(10H)-one

11-(4-bromophenyl)-3-(tetrahydro-2H-pyran-2-yl)benzo[f]pyridazino[4,5-b][1,4]oxazepine-4,10(3H,11H)-dione

Refernces

• 1、 Zhu, Zhen-Wei,Shi, Lei,Ruan, Xiao-Ming,Yang, Ying,Li, Huan-Qiu,Xu, Suo-Ping,Zhu, Hai-Liang. "Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: Potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase". experimental part. p. 37 - 45. Retrieved 2011/10/30.
• 2、 Achhra,Kulkarni. "Synthesis and β-adrenergic blocking activity of 1-isopropylamino-3 [2-substituted phenoxy]-2-propanols". . p. 162 - 163. Retrieved 2007/10/06.