ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

Base Information

Chemical Name:ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate
CAS No.:152775-84-3
Molecular Formula:C₁₉H₂₃N₅O₄
Molecular Weight:385.423
Hs Code.:

Synonyms:ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

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Chemical Property of ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

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Technology Process of ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

There total 7 articles about ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.5%

: 14337-43-0
ethyl 2-chloro-2-(hydroxyimino)acetate

: 152775-48-9
5-<3,5-dimethyl-4-(4-pentyn-1-yloxy)phenyl>-2-methyl-2H-tetrazole

: 152775-84-3
ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

Guidance literature:: With triethylamine; In chloroform; for 18h; Heating;
DOI:10.1021/jm00074a004

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 152775-84-3
ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

2: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; chloroform;
DOI:10.1021/jm00074a004

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 152775-84-3
ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 93.2 percent / K₂CO₃ / acetone / 18 h / Heating

2: 62 percent / NaN₃, NH₄Cl / dimethylformamide / 24 h / 110 °C

3: 67 percent / K₂CO₃ / acetonitrile / 1 h / Heating

4: 96 percent / BBr₃ / CH₂Cl₂

5: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

6: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

With sodium azide; boron tribromide; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00074a004