(4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

Base Information

Chemical Name:(4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole
CAS No.:716368-89-7
Molecular Formula:C₂₂H₂₅NOSe
Molecular Weight:398.407
Hs Code.:

Synonyms:(4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

Chemical Property:

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Technology Process of (4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

There total 4 articles about (4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 4392-24-9
Cinnamyl bromide

: 154701-60-7
2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole

: 716368-89-7
(4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

Guidance literature:: 2-(2-bromophenyl)-4-(1,1-dimethylethyl)-4,5-dihydro-(4S)-oxazole; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

With selenium; In tetrahydrofuran; pentane; at -78 - 0 ℃; for 1h;

Cinnamyl bromide; In tetrahydrofuran; pentane; at 0 ℃; for 1h;
DOI:10.1039/b316502g

Reference yield:

: 112245-13-3
(S)-tert-leucinol

: 716368-89-7
(4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂

2.1: SOCl₂ / CH₂Cl₂

3.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: Se / tetrahydrofuran; pentane / 1 h / -78 - 0 °C

3.3: 61 percent / tetrahydrofuran; pentane / 1 h / 0 °C

With thionyl chloride; tert.-butyl lithium; triethylamine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/b316502g

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 716368-89-7
(4S)-tert-butyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂

2.1: SOCl₂ / CH₂Cl₂

3.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: Se / tetrahydrofuran; pentane / 1 h / -78 - 0 °C

3.3: 61 percent / tetrahydrofuran; pentane / 1 h / 0 °C

With thionyl chloride; tert.-butyl lithium; triethylamine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/b316502g