(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

Base Information

Chemical Name:(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)
CAS No.:1289559-56-3
Molecular Formula:C₆₇H₆₈O₁₁Si
Molecular Weight:1077.36
Hs Code.:

Synonyms:(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

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Technology Process of (R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

There total 7 articles about (R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1289559-55-2
(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diol

: 1486-48-2
3,4,5-tribenzyloxybenzoic acid

: 1289559-56-3
(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.tetasy.2010.11.032

Reference yield:

: 844867-18-1
(+/-)-2-acetoxy-3-methylenesuccinic acid dimethyl ester

: 1289559-56-3
(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

Guidance literature:: Multi-step reaction with 5 steps

1: Pseudomonas cepacia lipase / water; Petroleum ether; benzene / 84 h / 50 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

2: hydrogenchloride; water / methanol / 0 °C

3: 1H-imidazole / 6 h / 0 - 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / -78 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; Pseudomonas cepacia lipase; water; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; toluene; Petroleum ether; benzene;
DOI:10.1016/j.tetasy.2010.11.032

Reference yield:

: 617-52-7
Dimethyl itakonate

: 1289559-56-3
(R)-2-((tert-butyldimethylsilyl)oxy)-3-methylenebutane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)

Guidance literature:: Multi-step reaction with 6 steps

1: selenium(IV) oxide / 5 h / Reflux

2: Pseudomonas cepacia lipase / water; Petroleum ether; benzene / 84 h / 50 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

3: hydrogenchloride; water / methanol / 0 °C

4: 1H-imidazole / 6 h / 0 - 20 °C

5: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / -78 °C

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; selenium(IV) oxide; Pseudomonas cepacia lipase; water; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; toluene; Petroleum ether; benzene;
DOI:10.1016/j.tetasy.2010.11.032