Technology Process of 2,3-dihydroxy-2-(hydroxymethyl)butane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate)
There total 8 articles about 2,3-dihydroxy-2-(hydroxymethyl)butane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-((tert-butyldimethylsilyl)oxy)-2-hydroxy-2-(hydroxy-methyl)butane-1,4-diyl bis(3,4,5-tris(benzyloxy)benzoate);
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
With
ammonium chloride;
DOI:10.1016/j.tetasy.2010.11.032
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Pseudomonas cepacia lipase / water; Petroleum ether; benzene / 84 h / 50 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
2: hydrogenchloride; water / methanol / 0 °C
3: 1H-imidazole / 6 h / 0 - 20 °C
4: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / -78 °C
5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C
6: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tert-butyl alcohol / 6 h / 20 °C
7: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C
With
1H-imidazole; hydrogenchloride; dmap; osmium(VIII) oxide; Pseudomonas cepacia lipase; tetrabutyl ammonium fluoride; water; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; Petroleum ether; tert-butyl alcohol; benzene;
DOI:10.1016/j.tetasy.2010.11.032
- Guidance literature:
-
Multi-step reaction with 8 steps
1: selenium(IV) oxide / 5 h / Reflux
2: Pseudomonas cepacia lipase / water; Petroleum ether; benzene / 84 h / 50 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
3: hydrogenchloride; water / methanol / 0 °C
4: 1H-imidazole / 6 h / 0 - 20 °C
5: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / -78 °C
6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C
7: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tert-butyl alcohol / 6 h / 20 °C
8: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C
With
1H-imidazole; hydrogenchloride; dmap; selenium(IV) oxide; osmium(VIII) oxide; Pseudomonas cepacia lipase; tetrabutyl ammonium fluoride; water; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; Petroleum ether; tert-butyl alcohol; benzene;
DOI:10.1016/j.tetasy.2010.11.032