tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313439-97-2
Molecular Formula:C₃₂H₃₄N₄O₃
Molecular Weight:522.647
Hs Code.:

Synonyms:tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

There total 6 articles about tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1313439-96-1
methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-6-methyl-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

: 1313439-97-2
tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With hydrazine hydrate; In ethanol; for 23h; Inert atmosphere; Reflux;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1313439-97-2
tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 18 h / 80 °C / Inert atmosphere

2.1: acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

3.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere

3.2: 0.58 h / 20 °C / Inert atmosphere

3.3: 1.5 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

4.2: 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

5.2: 4 h / 0 - 20 °C

6.1: hydrazine hydrate / ethanol / 23 h / Inert atmosphere; Reflux

With potassium tert-butylate; hydrazine hydrate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 1313439-94-9
methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

: 1313439-97-2
tert-butyl (1-(4-(3a-methyl-3-oxo-8-phenyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C

2.1: hydrazine hydrate / ethanol / 23 h / Inert atmosphere; Reflux

With potassium tert-butylate; hydrazine hydrate; In tetrahydrofuran; ethanol;