methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

Base Information

Chemical Name:methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate
CAS No.:1313439-94-9
Molecular Formula:C₃₂H₃₄N₂O₅
Molecular Weight:526.632
Hs Code.:

Synonyms:methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

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Chemical Property of methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

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Technology Process of methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

There total 4 articles about methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 1313439-93-8
tert-butyl (1-(4-(6-(bis(methylthio)methylene)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinolin-2-yl)phenyl)cyclobutyl)carbamate

: 1313439-94-9
methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

Guidance literature:: methanol; tert-butyl (1-(4-(6-(bis(methylthio)methylene)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinolin-2-yl)phenyl)cyclobutyl)carbamate; With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1313439-94-9
methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18 h / 80 °C / Inert atmosphere

2.1: acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

3.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere

3.2: 0.58 h / 20 °C / Inert atmosphere

3.3: 1.5 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

4.2: 20 °C

With potassium tert-butylate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1247897-74-0
tert-butyl (1-(4-(3-(dimethylamino)-2-phenylacryloyl)phenyl)cyclobutyl)carbamate

: 1313439-94-9
methyl 2-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

2.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere

2.2: 0.58 h / 20 °C / Inert atmosphere

2.3: 1.5 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C / Inert atmosphere

3.2: 20 °C

With potassium tert-butylate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol;