1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate
CAS No.:851635-10-4
Molecular Formula:C₂₄H₃₃N₅O₃
Molecular Weight:439.558
Hs Code.:

Synonyms:1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

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Chemical Property of 1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

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Technology Process of 1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

There total 8 articles about 1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851635-09-1
2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 851635-10-4
1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: C₂₃H₃₅N₃O₅

: 851635-10-4
1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 18 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 851635-10-4
1,1-dimethylethyl [2-({1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4 h / 20 °C

2.1: triethyloxonium hexaflourophosphate / dichloromethane / 48 h / 20 °C

2.2: 24 h / 60 °C

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 18 h / 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 18 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With 4-methyl-morpholine; sodium tris(acetoxy)borohydride; sodium hydride; triethyloxonium hexaflourophosphate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;