[(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester

Base Information

• Chemical Name: [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester
• CAS No.: 625840-35-9
• Molecular Formula: C₁₇H₂₇N₃O₂
• Molecular Weight: 305.42
• Mol file: 625840-35-9.mol

Synonyms:[(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester

Chemical Property of [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester

There total 1 articles about [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(1-carbamoyl-2-methyl-propyl)-carbamicacidtert-butyl ester (70717-76-9) + benzylamine (100-46-9) → [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester (625840-35-9)

Guidance literature:

(R)-(1-carbamoyl-2-methyl-propyl)-carbamicacidtert-butyl ester; With triethyloxonium hexaflourophosphate; In dichloromethane; at 20 ℃; for 48h;

benzylamine; In ethanol; at 60 ℃; for 24h;

Reference yield:

ethyl 2-chloroformylpropanoate (50496-34-9) + [(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester (625840-35-9) → C23H35N3O5

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

[(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester (625840-35-9) → 2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile (851635-09-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 18 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 18 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium hydride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(R)-(1-carbamoyl-2-methyl-propyl)-carbamicacidtert-butyl ester

benzylamine

Downstream raw materials:

2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

[1-(3-benzyl-5-methyl-6-hydroxy-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid t-butyl ester

[1-(3-benzyl-5-methyl-6-cyano-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid-t-butyl ester

N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide