2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Base Information

Chemical Name:2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile
CAS No.:851635-09-1
Molecular Formula:C₁₇H₂₀N₄O
Molecular Weight:296.372
Hs Code.:

Synonyms:2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

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Chemical Property of 2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

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Technology Process of 2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

There total 7 articles about 2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625840-39-3
[1-(3-benzyl-5-methyl-6-cyano-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid-t-butyl ester

: 851635-09-1
2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 625840-40-6
[1-(3-benzyl-5-methyl-6-hydroxy-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid t-butyl ester

: 851635-09-1
2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 18 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium hydride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 851635-08-0
C₂₂H₂₈F₃N₃O₆S

: 851635-09-1
2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;