C₁₇H₁₆FN₅O₃

Base Information

Chemical Name:C₁₇H₁₆FN₅O₃
CAS No.:1087353-97-6
Molecular Formula:C₁₇H₁₆FN₅O₃
Molecular Weight:357.344
Hs Code.:

C<sub>17</sub>H<sub>16</sub>FN<sub>5</sub>O<sub>3</sub>

Synonyms:C₁₇H₁₆FN₅O₃

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Chemical Property of C₁₇H₁₆FN₅O₃

Chemical Property:

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Technology Process of C₁₇H₁₆FN₅O₃

There total 14 articles about C₁₇H₁₆FN₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1087352-53-1
5-(R)-azidomethyl-3-[3-fluoro-4-(4-pyrazol-1-ylmethyl-oxazol-2-yl)-phenyl]-oxazolidin-2-one

: 1087353-97-6
C₁₇H₁₆FN₅O₃

Guidance literature:: 5-(R)-azidomethyl-3-[3-fluoro-4-(4-pyrazol-1-ylmethyl-oxazol-2-yl)-phenyl]-oxazolidin-2-one; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

With water; In tetrahydrofuran; at 75 ℃; for 1.5h;

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 1087353-97-6
C₁₇H₁₆FN₅O₃

Guidance literature:: Multi-step reaction with 16 steps

1.1: chromium(VI) oxide; sulfuric acid; acetic acid / water / 3 h / 100 °C

2.1: triethylamine / dmap / dichloromethane / 2 h / 10 - 20 °C

3.1: iron; ammonium chloride / ethanol; water / 1 h / 95 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 19 h / 0 - 50 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

7.1: Burgess Reagent / tetrahydrofuran / 3 h / 75 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

8.2: 0.5 h / 0 °C

9.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

10.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

10.2: -78 - 20 °C

11.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

12.1: sodium azide / N,N-dimethyl-formamide / 2 h / 75 °C

13.1: water; acetic acid / tetrahydrofuran / 16 h / 20 °C

14.1: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

15.1: potassium carbonate / acetonitrile / 20 h / 85 °C

16.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

16.2: 1.5 h / 75 °C

With 1H-imidazole; chromium(VI) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; sodium azide; Burgess Reagent; sulfuric acid; water; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; dmap; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1087353-97-6
C₁₇H₁₆FN₅O₃

Guidance literature:: Multi-step reaction with 15 steps

1.1: triethylamine / dmap / dichloromethane / 2 h / 10 - 20 °C

2.1: iron; ammonium chloride / ethanol; water / 1 h / 95 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 19 h / 0 - 50 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

6.1: Burgess Reagent / tetrahydrofuran / 3 h / 75 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

7.2: 0.5 h / 0 °C

8.1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

9.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

9.2: -78 - 20 °C

10.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

11.1: sodium azide / N,N-dimethyl-formamide / 2 h / 75 °C

12.1: water; acetic acid / tetrahydrofuran / 16 h / 20 °C

13.1: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

14.1: potassium carbonate / acetonitrile / 20 h / 85 °C

15.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

15.2: 1.5 h / 75 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; sodium azide; Burgess Reagent; water; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; dmap; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;