1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Base Information

• Chemical Name: 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole
• CAS No.: 1038988-09-8
• Molecular Formula: C₂₁H₂₄BrN₃O₃S
• Molecular Weight: 478.41

Synonyms:1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Chemical Property of 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

Chemical Property:

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Technology Process of 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole

There total 5 articles about 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methylpiperazine-1-yl methyl)-1H-indole (1038988-57-6) + 2-bromo-4-methoxybenzenesulfonyl chloride (23095-16-1) → 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole (1038988-09-8)

Guidance literature:

4-(4-methylpiperazine-1-yl methyl)-1H-indole; With sodium hydride; at 10 - 25 ℃; Inert atmosphere;

2-bromo-4-methoxybenzenesulfonyl chloride; at 10 - 25 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.10.057

Reference yield:

(2-methyl-3-nitrophenyl)(4-methylpiperazin-1-yl)methanone (349395-92-2) → 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole (1038988-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

2.1: hydrazine hydrate / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 68 °C / Inert atmosphere

4.1: sodium hydride / 10 - 25 °C / Inert atmosphere

4.2: 10 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; hydrazine hydrate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.057

Reference yield:

(1H-indol-4-yl)(4-methylpiperazin-1-yl)methanone (1038988-60-1) → 1-(2-bromo-4-methoxybenzenesulfonyl)-4-(4-methylpiperazin-1-ylmethyl)-1H-indole (1038988-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 68 °C / Inert atmosphere

2.1: sodium hydride / 10 - 25 °C / Inert atmosphere

2.2: 10 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.10.057

upstream raw materials:

(2-methyl-3-nitrophenyl)(4-methylpiperazin-1-yl)methanone

1-methyl-piperazine

(1H-indol-4-yl)(4-methylpiperazin-1-yl)methanone

4-(4-methylpiperazine-1-yl methyl)-1H-indole

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