2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

Base Information

Chemical Name:2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol
CAS No.:196883-02-0
Molecular Formula:C₂₄H₂₂N₂O₆S₂
Molecular Weight:498.58
Hs Code.:

Synonyms:2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

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Chemical Property of 2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

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Technology Process of 2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

There total 4 articles about 2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1027657-45-9
1-benzenesulfonyl-3,3-dimethoxy-piperidine

: N-(3-methoxy-4-oxo-cyclohexa-2,5-dienylidene)-benzenesulfonamide

: 196883-02-0
2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

Guidance literature:: 1-benzenesulfonyl-3,3-dimethoxy-piperidine; With aluminium trichloride; triethylamine; In diethyl ether; at 20 ℃;

N-(3-methoxy-4-oxo-cyclohexa-2,5-dienylidene)-benzenesulfonamide; With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; for 10h;

With ammonium chloride; In dichloromethane; for 0.5h; Further stages.;
DOI:10.1021/jo9916176

Reference yield: 58.0%

: 168648-80-4
N-[3-Benzyloxy-4-oxo-cyclohexa-2,5-dien-(E)-ylidene]-benzenesulfonamide

: 196882-98-1
1-Benzenesulfonyl-5-methoxy-1,2,3,6-tetrahydro-pyridine

: 196883-02-0
2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

Guidance literature:: With titanium(IV) isopropylate; titanium tetrachloride; at -78 ℃;
DOI:10.1016/S0040-4039(97)01391-9

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 196883-02-0
2,9-bis-benzenesulfonyl-7-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / K₂CO₃ / H₂O; CHCl₃ / 20 °C

2.1: p-TsOH*H₂O / 10 h

3.1: AlCl₃; Et₃N / diethyl ether / 20 °C

3.2: TiCl₄; Ti(OiPr)4 / CH₂Cl₂ / 10 h / -78 - 20 °C

3.3: 71 percent / aq. NH₄Cl / CH₂Cl₂ / 0.5 h

With aluminium trichloride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In diethyl ether; chloroform; water; 1.1: Substitution / 2.1: Addition / 3.1: Elimination / 3.2: cyclocondensation / 3.3: Elimination;
DOI:10.1021/jo9916176