N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide

Base Information

• Chemical Name: N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide
• CAS No.: 1028303-96-9
• Molecular Formula: C₁₇H₁₉N₅O₄
• Molecular Weight: 357.369
• Mol file: 1028303-96-9.mol

Synonyms:N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide

Chemical Property of N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide

There total 2 articles about N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propoxy-5-nitrobenzoyl chloride (116478-02-5) + 5-amino-4-cyano-3-methyl-1-ethyl-(1H)-pyrazole (102997-29-5) → N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide (1028303-96-9)

Guidance literature:

With pyridine; at 60 ℃; for 3h;

DOI:10.1021/jm950812j

Reference yield:

(1-ethoxyethylidene)malononitrile (5417-82-3) → N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide (1028303-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CH₃ONa / 1.) CH₃OH, reflux, 15 min, 2.) CH₃OH, reflux, 2 h

2: pyridine / 3 h / 60 °C

With pyridine; sodium methylate;

DOI:10.1021/jm950812j

Reference yield:

N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide (1028303-96-9) → 1-Ethyl-3-methyl-6-(2-propoxy-5-acetamidophenyl)-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH, 30percent H₂O₂ / 18 h / 100 °C

2: H₂ / 10percent Pd/C / ethanol / Ambient temperature

3: Et₃N / tetrahydrofuran / Ambient temperature

With sodium hydroxide; hydrogen; dihydrogen peroxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm950812j

upstream raw materials:

2-propoxy-5-nitrobenzoyl chloride

5-amino-4-cyano-3-methyl-1-ethyl-(1H)-pyrazole

(1-ethoxyethylidene)malononitrile

Downstream raw materials:

1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one

1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one