Technology Process of (S)-2-[3-(naphthalen-1-yloxy)-1-phenylpropyl]isoindole-1,3-dione
There total 7 articles about (S)-2-[3-(naphthalen-1-yloxy)-1-phenylpropyl]isoindole-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 25 ℃;
for 4h;
stereospecific reaction;
Inert atmosphere;
DOI:10.1080/00397911.2011.575522
- Guidance literature:
-
α-naphthol;
With
potassium carbonate;
In
acetone;
at 70 ℃;
for 2h;
C24H21NO5S;
In
acetone;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / n-Undecane; dichloromethane / 3.5 h / -20 °C / Molecular sieve
2: sodium bis(2-methoxyethoxy)aluminium dihydride / 1,2-dimethoxyethane; toluene / 3 h / 0 - 25 °C / Inert atmosphere
3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 h / 25 °C / Inert atmosphere
4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; di-isopropyl azodicarboxylate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; 1,2-dimethoxyethane; n-Undecane; dichloromethane; toluene;
1: Sharpless epoxidation / 3: Mitsunobu reaction / 4: Mitsunobu reaction;
DOI:10.1080/00397911.2011.575522
