3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene

Base Information

• Chemical Name: 3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene
• CAS No.: 135429-76-4
• Molecular Formula: C₁₇H₁₈N₂O₅S
• Molecular Weight: 362.406
• Mol file: 135429-76-4.mol

Synonyms:3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene

Chemical Property of 3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene

There total 2 articles about 3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) + 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester (85006-31-1) → 3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene (135429-76-4)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile; Ambient temperature;

DOI:10.1016/0223-5234(91)90024-H

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → 3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene (135429-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / hexamethylphosphoric acid triamide; acetonitrile / 0.25 h / -5 - 0 °C

2: 99.3 percent / hexamethylphosphoric acid triamide; acetonitrile / Ambient temperature

With thionyl chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile;

DOI:10.1016/0223-5234(91)90024-H

Reference yield: 81.3%

3-((benzyloxycarbonyl)glycyl)amino-2-methoxycarbonyl-4-methylthiophene (135429-76-4) → 3-((benzyloxycarbonyl)glycyl)amino-2-hydroxymethyl-4-methylthiophene (135429-74-2)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 96h; Ambient temperature;

DOI:10.1016/0223-5234(91)90024-H

upstream raw materials:

N-(benzyloxycarbonyl)glycyl chloride

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

3-((benzyloxycarbonyl)glycyl)amino-2-hydroxymethyl-4-methylthiophene

2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole