3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester

Base Information

• Chemical Name: 3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester
• CAS No.: 202057-94-1
• Molecular Formula: C₁₈H₁₉NO₆
• Molecular Weight: 345.352
• Mol file: 202057-94-1.mol

Synonyms:3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester

Chemical Property of 3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester

There total 1 articles about 3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4-Methoxycarbonylmethyl-3-methyl-5-trichloromethyl-1H-pyrrole-2-carboxylic acid benzyl ester (87281-59-2) → 3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester (202057-94-1)

Guidance literature:

With sodium acetate; at 50 ℃; for 72h;

DOI:10.1021/jo971807l

Reference yield: 68.0%

3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester (202057-94-1) → 3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 2-methyl ester (202057-95-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h;

DOI:10.1021/jo971807l

Reference yield:

3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester 2-methyl ester (202057-94-1) → 2,8,12,18-tetravinyl-3,7,13,17-tetramethyl-5,15-diphenylporphyrin

Guidance literature:

Multi-step reaction with 11 steps

1: 68 percent / H₂ / Pd/C / ethanol / 2 h

2: 97 percent / I₂, KI, NaHCO₃ / ethanol; H₂O / 1 h / Heating

3: 74 percent / H₂, NaOAc / Pd/C / methanol / 2 h / 2585.7 Torr

4: 80 percent / p-TsOH / CHCl₃ / 2 h / Heating

5: 66 percent / B₂H₆ / tetrahydrofuran / 26 h / 25 °C

6: 74 percent / KOH / ethanol; H₂O / 110 °C

7: 62 percent / pyridine / 2 h / 25 °C

8: 1.) p-TsOH / 1.) CH₂Cl₂, MeOH, 25 deg C, 72 h, 2.) Py, 2 h

9: 90 percent / aq. H₂SO₄ / methanol / 24 h / 25 °C

10: 52 percent / mesyl chloride / dimethylformamide / 18 h / 75 °C

11: 72 percent / aq. KOH / pyridine / 3 h / Heating

With potassium hydroxide; sulfuric acid; hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; potassium iodide; diborane; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1021/jo971807l

upstream raw materials:

methanol

4-Methoxycarbonylmethyl-3-methyl-5-trichloromethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Downstream raw materials:

3-Methoxycarbonylmethyl-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 2-methyl ester

2,8-di(2-acetoxyethyl)-3,7-dimethyl-5-phenyldipyrrylmethane-1,9-dicarboxylic acid

2,8-bis(2-hydroxyethyl)-3,7-dimethyl-5-phenyl-1,9-diformyldipyrrylmethane

2,8-bis(2-hydroxyethyl)-3,7-dimethyl-5-phenyl-1,9-dicarboxydipyrrylmethane