(2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine

Base Information

• Chemical Name: (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine
• CAS No.: 1160714-39-5
• Molecular Formula: C₂₄H₃₃N₃
• Molecular Weight: 363.546
• Mol file: 1160714-39-5.mol

Synonyms:(2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine

Chemical Property of (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine

There total 10 articles about (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-methyl-piperazine (109-01-3) + ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine (951155-03-6) → (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine (1160714-39-5)

Guidance literature:

With palladium; In 2-methyltetrahydrofuran; tert-Amyl alcohol; at 50 ℃;

DOI:10.1021/acs.joc.8b00309

Reference yield:

1-methyl-piperazine (109-01-3) + ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride (1394290-38-0) → (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine (1160714-39-5)

Guidance literature:

((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride; With sodium hydroxide; In toluene;

1-methyl-piperazine; With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene;

DOI:10.1021/jo300277y

Reference yield:

1-methyl-piperazine (109-01-3) + ((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride (1394290-38-0) → (2R)-5-methyl-8-(4-methylpiperazin-1-yl)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydro-naphthalen-2-amine (1160714-39-5) + ((R)-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine

Guidance literature:

((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride; With sodium hydroxide; In toluene; at 25 - 60 ℃;

1-methyl-piperazine; With palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 40 - 100 ℃; for 4h;

DOI:10.1021/op8000146

upstream raw materials:

1-methyl-piperazine

((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine hydrochloride

2-bromo-5-methylphenylacetic acid

((R)-8-bromo-5-methyl-1,2,3,4-tetrahydronaphthalen-2-yl)-(S)-1-(phenylethyl)amine