3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

Base Information

Chemical Name:3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid
CAS No.:1360904-71-7
Molecular Formula:C₂₃H₂₀N₂O₆
Molecular Weight:420.422
Hs Code.:

Synonyms:3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

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Chemical Property of 3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

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Technology Process of 3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

There total 7 articles about 3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1360904-18-2
7-phenyl-2-(3,4,5-trimethoxy-phenyl)-furo[3,2-b]pyridine

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1360904-71-7
3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

Guidance literature:: 7-phenyl-2-(3,4,5-trimethoxy-phenyl)-furo[3,2-b]pyridine; With potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; water; at 150 ℃; for 3h; Microwave irradiation;

2-Amino-2-methyl-1-propanol; In N,N-dimethyl-formamide; at 20 ℃; for 4.5h;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1360904-71-7
3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 0.08 h / Inert atmosphere

1.2: 18 h / 500 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

3.1: trichlorophosphate / 2 h / 100 °C / Sealed tube

4.1: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere

5.1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 150 °C / Microwave irradiation

6.1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 150 °C / Microwave irradiation

7.1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 3 h / 150 °C / Microwave irradiation

7.2: 4.5 h / 20 °C

With potassium fluoride; N-iodo-succinimide; copper(l) iodide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; In 1,4-dioxane; dichloromethane; water; acetonitrile; 5.1: Suzuki Coupling / 6.1: Suzuki Coupling;

Reference yield:

: 1360904-14-8
7-chloro-2-(3,4,5-trimethoxy-phenyl)furo[3,2-b]pyridine

: 1360904-71-7
3-[[2-(3,4,5-trimethoxyphenyl)furo[3,2-b]pyridin-7-yl]amino]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 0.75 h / 150 °C / Microwave irradiation

2.1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 3 h / 150 °C / Microwave irradiation

2.2: 4.5 h / 20 °C

With potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; water; 1.1: Suzuki Coupling;