(E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid

Base Information

• Chemical Name: (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid
• CAS No.: 111751-17-8
• Molecular Formula: C₁₉H₁₇ClO₄
• Molecular Weight: 344.795

Synonyms:(E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid

Chemical Property of (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid

Chemical Property:

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Technology Process of (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid

There total 3 articles about (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid (111751-14-5) → (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid (111751-17-8)

Guidance literature:

With hydrogenchloride; In acetic acid; for 3h; reflux on a water-bath;

DOI:10.1002/jhet.5570240114

Reference yield:

4-(p-chlorophenyl)-2-oxobutanoic acid (76400-21-0) → (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid (111751-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / potassium hydroxide / H₂O / 48 h / 0 °C

2: 95 percent / 36percent hydrochloric acid / acetic acid / 3 h / reflux on a water-bath

With hydrogenchloride; potassium hydroxide; In water; acetic acid;

DOI:10.1002/jhet.5570240114

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → (E)-4-(4-Chloro-phenyl)-2-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-but-2-enoic acid (111751-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / potassium hydroxide / H₂O / 48 h / 0 °C

2: 95 percent / 36percent hydrochloric acid / acetic acid / 3 h / reflux on a water-bath

With hydrogenchloride; potassium hydroxide; In water; acetic acid;

DOI:10.1002/jhet.5570240114

upstream raw materials:

2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid

4-(p-chlorophenyl)-2-oxobutanoic acid

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

4-[2-(4-Chloro-phenyl)-ethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one

2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one

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